Induction of cytoprotective autophagy in PC-12 cells by cadmium
نویسندگان
چکیده
منابع مشابه
Induction of cytoprotective autophagy in PC-12 cells by cadmium.
Laboratory data have demonstrated that cadmium (Cd) may induce neuronal apoptosis. However, little is known about the role of autophagy in neurons. In this study, cell viability decreased in a dose- and time-dependent manner after treatment with Cd in PC-12 cells. As cells were exposed to Cd, the levels of LC3-II proteins became elevated, specific punctate distribution of endogenous LC3-II incr...
متن کاملCadmium-induced autophagy is mediated by oxidative signaling in PC-12 cells and is associated with cytoprotection.
Oxidative stress induced by cadmium (Cd) is a common phenomenon that has been observed in numerous studies. However, the underlying mechanism remains unknown. Recently, exposure of PC-12 cells to Cd has been shown to activate autophagy, which acts as a temporary survival pathway under stressful conditions by delaying the occurrence of apoptosis. The present study investigated the impact of oxid...
متن کاملNeferine attenuates the protein level and toxicity of mutant huntingtin in PC-12 cells via induction of autophagy.
Mutant huntingtin aggregation is highly associated with the pathogenesis of Huntington's disease, an adult-onset autosomal dominant disorder, which leads to a loss of motor control and decline in cognitive function. Recent literature has revealed the protective role of autophagy in neurodegenerative diseases through degradation of mutant toxic proteins, including huntingtin or a-synuclein. Thro...
متن کاملinvestigation of apoptosis induction in differentiated pc-12 cells after exposure to hydrostatic pressure
objective: hydrostatic pressure is crucial component of cell environment and fundamental physical quantity, also it is the main factor of both cell integrity and function. pressure variation disorder, beyond physiological limits, may lead to pathological states. in this study, we examined the effect of hydrostatic pressure on apoptosis induction, viability, morphology, adhesion potency to subst...
متن کاملProtective effect of adult olfactory ensheathing cells against 6-OHDA toxicity in PC-12 cells
Olfactory ensheathing cells (OEC) have been successfully used to stimulate the growth of injured fibers and to promote functional recovery within the injured adult CNS. These cells exhibit functional properties, which are known to be involved in axonal elongation. OEC express high level of growth factors including NGF, GDNF, BDNF and NT-3, which are known to play an important role in nerve rege...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2013
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2013.07.050